DUBOUE LAB
Welcome to the Duboué Lab!
Our lab, based at the MacArthur Campus of Florida Atlantic University, is part of the Jupiter Life Science Initiative. The lab is dedicated to understanding how the brain drives behavior and how modifications to neural circuits shape responses to the environment. Our research explores the neurobiology of behavioral adaptation using small fish models, particularly zebrafish (Danio rerio) and cavefish (Astyanax mexicanus). These powerful model organisms help us investigate the genetic, developmental, and neural mechanisms underlying behavioral evolution, resilience, and plasticity.
Explore our site to learn more about our research, and feel free to contact us with any questions!
RECENT PUBLICATIONS
Kozol, RA, Canavan, A, Tolentino, B, Keene, A.C., Kowalko, JE, Duboué, E.R. (2024) Evolution of a central dopamine circuit underlies adaptation of light-evoked sensorimotor response in the blind cavefish, Astyanax mexicanus. bioRxiv​
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Kozol, R. A., Conith, A. J., Yuiska, A., Cree-Newman, A., Tolentino, B., Banesh, K., Paz, A., Lloyd, E., Kowalko, J. E., Keene, A. C., Albertson, R. C., & Duboué, E. R. (2023). A brain-wide analysis maps structural evolution to distinct anatomical modules. Elife. Jul 27;12:e80777​​
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Lloyd, E., McDole, B., Privat, M., Jaggard, J. B., Duboué, E.R., Sumbre, G., & Keene, A. (2022). Blind cavefish retain functional connectivity in the tectum despite loss of retinal input. Curr Biol. Sep 12;32(17):3720-3730.e3.​
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Chin, J.S.R, Loomis, C.L., Albert, L.T., Medina-Trenche, S., Kowalko, J.E., Keene, A.C., Duboué, E.R. (2020) Analysis of stress responses in Astyanax larvae reveals heterogeneity among different populations. Journal of Experiemntal Zoology, Part B
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Chin, J.S.R., Gassant, C., Amaral, P., Lloyd, E., Stahl B.A., Jaggard, J.B., Keene, A.C., Duboué, E.R. (2018)Convergence on reduced stress behavior in the Mexican blind cavefish. Dev Biol. 441(2): 319-327
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Jaggard, J.B., Stahl B.A., Lloyd, E., Prober, D.A., Duboué, E.R., and Keene, A.C. (2017) Hypocretin underliesthe evolution of sleep loss in the Mexican cavefish. eLife. 7. pii: e32637. doi: 10.7554/eLife.32637
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Duboué, E.R., Hong, E, Eldred, K.C., Halpern, M.E. (2017) Left Habenular Activity Attenuates Fear Responsesin Larval Zebrafish. Curr Biol, 27(14): 2154-2162.e3.
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